NDT 9513727
- Product Name
- NDT 9513727
- CAS No.
- 439571-48-9
- Chemical Name
- NDT 9513727
- Synonyms
- NDT 9513727;N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine;1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
- CBNumber
- CB82603001
- Molecular Formula
- C36H35N3O4
- Formula Weight
- 573.68
- MOL File
- 439571-48-9.mol
NDT 9513727 Property
- Boiling point:
- 723.1±62.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mM; Ethanol: 100 mM
- form
- A solid
- pka
- 6.69±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- 24448
- Product name
- NDT 9513727
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24448
- Product name
- NDT 9513727
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 24448
- Product name
- NDT 9513727
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 3333
- Product name
- NDT9513727
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $278
- Updated
- 2021/12/16
- Product number
- 3333
- Product name
- NDT9513727
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1170
- Updated
- 2021/12/16
NDT 9513727 Chemical Properties,Usage,Production
Description
NDT 9513727 is a competitive antagonist of the C5a receptor (C5aR; IC50 = 11.6 nM for human recombinant receptors) that has inverse agonist activity in a GTPγ[35S] assay. It is selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 μM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively). NDT 9513727 inhibits degranulation in U937 cells stimulated with C5a (IC50 = 7.1 nM). It also prevents neutropenia induced by human recombinant C5a in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques when administered at doses of 5 and 25 mg/kg.
Uses
NDT 9513727 is a selective, and potent inverse agonist of the human C5aR. NDT 9513727 has been shown to effectively inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo. These results suggest that NDT 9513727 is a promising candidate for the treatment of human inflammatory diseases.
storage
Store at +4°C